We are a part of the Biochemistry Laboratory in the Biology Department of
the Ecole Polytechnique and the Centre National de la Recherche Scientifique.
We are located in the Ecole Polytechnique, Palaiseau, just outside of Paris.
voice-mail: +33/(0)1 69 33 48 60; fax: +33/(0)1 69 33 49 09
snail-mail: Laboratoire de Biochimie, Ecole Polytechnique, 91128 Palaiseau, France.
My group uses computer modeling and simulation to study
structure-function relationships in proteins, as well as protein
evolution. We use state-of-the-art simulation techniques, including
computational protein design, molecular dynamics, continuum
electrostatics, and free energy
perturbation techniques, and a significant portion of our effort is
directed at the development of new
techniques as new needs arise. We are especially interested in protein
engineering, protein-ligand recognition, and the inverse protein
folding problem. We have taken part for many years in
the development of free energy perturbation techniques for proteins,
these techniques are now maturing into a reliable and remarkable tool.
Recent applications to aminoacyl-tRNA synthetases have provided
the translation of the genetic code. Protein design using directed
evolution is a new research direction in the group. We have recently
developed the Proteins@Home
distributed computing platform for structure prediction and design.
Thomas Simonson, professor.
David Mignon, engineer.
Guillaume Launay, Najette Amara, Alexey Aleksandrov, Anne Lopes, Ph.D. students.
Marcel Schmidt-an-Busch, postdoctoral fellow.
Former group members.
Some recent publications